Endocrine disrupting chemicals—how to strengthen safety assessment

Endocrine disrupting chemicals

The idea that xenobiotic chemicals could inappropriately modlate the endocrine system thereby causing detrimental effects n wildlife and humans was first proposed 20 years ago at the atershed Wingspread Conference [1,2]. These endocrine disruptng chemicals (EDCs) have long been controversial, with a great eal of discussion raging in the scientific literature. Much of this ontroversy has centere...

Endocrine Disrupting Pesticides

Endocrine Disrupting Chemicals: Interaction with Estrogen Receptors and in vitro Assessment of Endocrine Activity Potential

University of Konstanz and for coaching me through the project. Thanks to the Haematox group for the scientific but also personal support: you are not only colleagues but really good friends! Thanks to Dr. Michele Reni for the constant presence, for the optimism and for making endurable the therapy. Finally, this work is dedicated to the most important people in my life: mamma, papa' and Tommaso.

Cryptorchidism and endocrine disrupting chemicals

Prospective clinical studies have suggested that the rate of congenital cryptorchidism has increased since the 1950s. It has been hypothesized that this may be related to environmental factors. Testicular descent occurs in two phases controlled by Leydig cell-derived hormones insulin-like peptide 3 (INSL3) and testosterone. Disorders in fetal androgen production/action or suppression of Insl3 a...

Endocrine-disrupting chemicals: an Endocrine Society scientific statement.

There is growing interest in the possible health threat posed by endocrine-disrupting chemicals (EDCs), which are substances in our environment, food, and consumer products that interfere with hormone biosynthesis, metabolism, or action resulting in a deviation from normal homeostatic control or reproduction. In this first Scientific Statement of The Endocrine Society, we present the evidence t...